Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans

Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans

In the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is pro...

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Main Authors: Raphaela Geßele, Jacob Halatek, Laeschkir Würthner, Erwin Frey
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14317-w
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spelling doaj-f1a4a0ddcb864ea5b149df7b466f4af82021-05-11T08:59:28ZengNature Publishing GroupNature Communications2041-17232020-01-0111111210.1038/s41467-020-14317-wGeometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegansRaphaela Geßele0Jacob Halatek1Laeschkir Würthner2Erwin Frey3Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität MünchenArnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität MünchenArnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität MünchenArnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität MünchenIn the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is promoted by cytosolic dephosphorylation at onset and its steady state determined by minimising the length of the aPAR-pPAR interface.https://doi.org/10.1038/s41467-020-14317-w
collection DOAJ
language English
format Article
sources DOAJ
author Raphaela Geßele
Jacob Halatek
Laeschkir Würthner
Erwin Frey
spellingShingle Raphaela Geßele
Jacob Halatek
Laeschkir Würthner
Erwin Frey
Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
Nature Communications
author_facet Raphaela Geßele
Jacob Halatek
Laeschkir Würthner
Erwin Frey
author_sort Raphaela Geßele
title Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_short Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_full Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_fullStr Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_full_unstemmed Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans
title_sort geometric cues stabilise long-axis polarisation of par protein patterns in c. elegans
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description In the C. elegans zygote, (anterior) aPAR and (posterior) pPAR proteins are key to polarity maintenance, what factors determine the selection of the polarity axis remains unclear. Here authors formulate a reaction-diffusion model in realistic cell geometry and find that long-axis polarisation is promoted by cytosolic dephosphorylation at onset and its steady state determined by minimising the length of the aPAR-pPAR interface.
url https://doi.org/10.1038/s41467-020-14317-w
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AT jacobhalatek geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans
AT laeschkirwurthner geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans
AT erwinfrey geometriccuesstabiliselongaxispolarisationofparproteinpatternsincelegans
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