Acute phase CD8+ T lymphocytes against alternate reading frame epitopes select for rapid viral escape during SIV infection.

Acute phase CD8+ T lymphocytes against alternate reading frame epitopes select for rapid viral escape during SIV infection.

CD8+ T Lymphocytes (CTL) can control AIDS virus replication. However, natural selection favoring viral variants that escape CTL recognition is a common feature of both simian immunodeficiency virus (SIV) infection of macaques and HIV infection of humans. Emerging data indicate that CTL directed agai...

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Bibliographic Details
Main Authors: Andrew D Walsh, Benjamin N Bimber, Arpita Das, Shari M Piaskowski, Eva G Rakasz, Alexander T Bean, Philip A Mudd, Adam J Ericsen, Nancy A Wilson, Austin L Hughes, David H O'Connor, Nicholas J Maness
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3645990?pdf=render

Internet

http://europepmc.org/articles/PMC3645990?pdf=render

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