An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells

An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells

Recent advances in cellular therapies for patients with cancer, including checkpoint blockade and ex vivo-expanded, tumor-specific T cells, have demonstrated that targeting the immune system is a powerful approach to the elimination of tumor cells. Clinical efforts have also demonstrated limitations...

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Bibliographic Details
Main Authors: Nicole A. P. Lieberman, Kole DeGolier, Kristen Haberthur, Harrison Chinn, Kara W. Moyes, Myriam N. Bouchlaka, Kirsti L. Walker, Christian M. Capitini, Courtney A. Crane
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
immunotherapy
ex vivo expansion
adoptive transfer
clinical product
phenotypic analysis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00150/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00150/full

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