Unsupervised Clustering Reveals Distinct Subtypes of Biliary Atresia Based on Immune Cell Types and Gene Expression

Unsupervised Clustering Reveals Distinct Subtypes of Biliary Atresia Based on Immune Cell Types and Gene Expression

BackgroundBiliary atresia (BA) is a severe cholangiopathy of early infancy that destroys cholangiocytes, obstructs ductular pathways and if left untreated, culminates to liver cirrhosis. Mechanisms underlying the etiological heterogeneity remain elusive and few studies have attempted phenotyping BA....

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Bibliographic Details
Main Authors: Xiuqing Pang, Jing Cao, Shuru Chen, Zhiliang Gao, Guangjian Liu, Yutian Chong, Zhuanggui Chen, Jiao Gong, Xinhua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
autoimmune
perinatal infection
biliary atresia
immune cells and genes
unsupervised hierarchical clustering
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.720841/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.720841/full

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