The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation

The drug dimethyl fumarate (DMF) is in clinical use for the treatment of psoriasis and multiple sclerosis. In addition, it has recently been demonstrated to ameliorate skin pathology in mouse models of pemphigoid diseases, a group of autoimmune blistering diseases of the skin and mucous membranes. H...

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Bibliographic Details
Main Authors: Melanie Wannick, Julian C. Assmann, Jakob F. Vielhauer, Stefan Offermanns, Detlef Zillikens, Christian D. Sadik, Markus Schwaninger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
pemphigoid disease
G protein-coupled receptor
immunomodulatory therapy
autoimmune blistering skin disease
neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01890/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01890/full

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