Evolutionary Constraints to Viroid Evolution

Evolutionary Constraints to Viroid Evolution

We suggest that viroids are trapped into adaptive peaks as the result of adaptive constraints. The first one is imposed by the necessity to fold into packed structures to escape from RNA silencing. This creates antagonistic epistases, which make future adaptive trajectories contingent upon the first...

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Bibliographic Details
Main Authors: Santiago F. Elena, Gustavo Gómez, José-Antonio Daròs
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Viruses
Subjects:
epistasis
evolutionary constraints
genome complexity
mutation rate
RNA folding
viroid evolution
Online Access:http://www.mdpi.com/1999-4915/1/2/241/

Internet

http://www.mdpi.com/1999-4915/1/2/241/

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