In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

TAK1 (TGF-β Activated Kinase 1) is a MAPK kinase kinase, which activates the p38- and JNK-MAPK and NF-κB pathways downstream of receptors such as Toll-Like-, cytokine- and T-cell and B-cell receptors. Representing such an important node in the pro-inflammatory signal-transduction network, the functi...

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Bibliographic Details
Main Authors: Paul M Vink, Wendy M Smout, Lilian J Driessen-Engels, Alex M de Bruin, Dianne Delsing, Magda A Krajnc-Franken, Aswin J Jansen, Eric F Rovers, André A van Puijenbroek, Allard Kaptein, Martijn A Nolte, Anja Garritsen, Hans van Eenennaam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505428/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505428/?tool=EBI

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