Functional evaluation of genetic and environmental regulators of p450 mRNA levels.

Functional evaluation of genetic and environmental regulators of p450 mRNA levels.

Variations in the activities of Cytochrome P450s are one of the major factors responsible for inter-individual differences in drug clearance rates, which may cause serious toxicity or inefficacy of therapeutic drugs. Various mRNA level is one of the key factors for different activity of the major P4...

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Bibliographic Details
Main Authors: Dazhi Wang, Zhengwen Jiang, Zhongyang Shen, Hui Wang, Beilan Wang, Weihua Shou, Hong Zheng, Xun Chu, Jinxiu Shi, Wei Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187744?pdf=render

Internet

http://europepmc.org/articles/PMC3187744?pdf=render

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