Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

<p>Abstract</p> <p>Background</p> <p>Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers. Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed b...

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Bibliographic Details
Main Authors: Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus
Format: Article
Language:English
Published: SAGE Publishing 2011-10-01
Series:Molecular Pain
Subjects:
sEH
EET
CYP450
nociceptors
TRPA1
hyperalgesia
Online Access:http://www.molecularpain.com/content/7/1/78

Internet

http://www.molecularpain.com/content/7/1/78

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