The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K2P) potassium channels have recently been identified as targets for substances associated with typical trigeminal sensations, such as numbing and tingling. In addition,...

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Bibliographic Details
Main Authors: Leopoldo Raul Beltran, Corinna eDawid, Madeline eBeltran, Guenter eGisselmann, Katharina eDegenhardt, Klaus eMathie, Thomas eHofmann, Hanns eHatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Pharmacology
Subjects:
Capsaicin
K2P channels
Piperine
pungency
6-gingerol
polygodial
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00141/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00141/full

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