MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

Summary: MYC activates different metabolic programs in a cell-type- and cell-status-dependent manner. However, the role of MYC in inflammatory macrophages has not yet been determined. Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1 (HIF1), is involved in enhancin...

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Bibliographic Details
Main Authors: Seyeon Bae, Peter Sang Uk Park, Yeji Lee, Se Hwan Mun, Eugenia Giannopoulou, Takayuki Fujii, Kelvin P. Lee, Sara Nunes Violante, Justin R. Cross, Kyung-Hyun Park-Min
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006318

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http://www.sciencedirect.com/science/article/pii/S2211124721006318

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