Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro

Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro

Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a key enzyme involved in the metabolism of the endogenous nitric oxide synthase (NOS) inhibitors asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA). Increased DDAH1 expression and subsequent increased NO production have been recen...

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Bibliographic Details
Main Authors: Julie-Ann Hulin, Sara Tommasi, David Elliot, Arduino A. Mangoni
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
DDAH1
Nitric oxide
Vasculogenic mimicry
Breast cancer
ADMA
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218370781

Internet

http://www.sciencedirect.com/science/article/pii/S0753332218370781

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