Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance

Abstract Background Cerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it is nearly protein-free (~ 250-fold less) and contains about 2–20-fold less free amino acids, with the exception of glutamine (Gln) which is...

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Bibliographic Details
Main Authors: Elena Dolgodilina, Simone M. Camargo, Eva Roth, Brigitte Herzog, Virginia Nunes, Manuel Palacín, Francois Verrey
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Fluids and Barriers of the CNS
Subjects:
CSF
Online Access:https://doi.org/10.1186/s12987-020-0178-x