Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca2+ induced permeability transition

Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca2+ induced permeability transition

ecSOD function has prototypically been associated with the extracellular space due to its secretion and localization to the extracellular matrix. A myocyte-specific ecSOD transgenic mouse has shown that it can also be localized to the myocyte intracellular compartment and is capable of attenuating R...

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Bibliographic Details
Main Authors: Jianzhu eLuo, Detlef eObal, Neviana eDimova, Xian-Liang eTang, Gregg eRokosh
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Physiology
Subjects:
Mitochondria
Nitric Oxide
Reactive Oxygen Species
cardiac myocytes
ecSOD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00295/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00295/full

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