Divergent Contributions of Conserved Active Site Residues to Transcription by Eukaryotic RNA Polymerases I and II

Divergent Contributions of Conserved Active Site Residues to Transcription by Eukaryotic RNA Polymerases I and II

Multisubunit RNA polymerases (msRNAPs) exhibit high sequence and structural homology, especially within their active sites, which is generally thought to result in msRNAP functional conservation. However, we show that mutations in the trigger loop (TL) in the largest subunit of RNA polymerase I (Po...

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Bibliographic Details
Main Authors: Olga V. Viktorovskaya, Krysta L. Engel, Sarah L. French, Ping Cui, Paul J. Vandeventer, Emily M. Pavlovic, Ann L. Beyer, Craig D. Kaplan, David A. Schneider
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004063

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http://www.sciencedirect.com/science/article/pii/S2211124713004063

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