Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Abstract Microglia-mediated neuroinflammation has been implicated in the pathogenesis of Alzheimer’s disease (AD). Although microglia in aging and neurodegenerative disease model mice show a loss of homeostatic phenotype and activation of disease-associated microglia (DAM), a correlation between tho...

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Bibliographic Details
Main Authors: Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C. Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Animal model
Next generation sequence
Microglia
Precuneus
Neuroinflammation
Online Access:https://doi.org/10.1186/s40478-020-01099-x

Internet

https://doi.org/10.1186/s40478-020-01099-x

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