17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation

17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation

Liver cancer is associated with high mortality, particularly in patients infected with the hepatitis B virus. Treatment methods remain very limited. Here, we explored the effects of 17β-estradiol (E2) on apoptosis of various liver cell lines (LO2, HepG2, and HepG2.2.15 cells). Within a certain conce...

Full description

Bibliographic Details
Main Authors: Yusheng Guo, Xiangsheng Cai, Hanwei Lu, Qiqi Li, Ying Zheng, Zefang Lin, Zexiong Cheng, Maoxiang Yang, Li Zhang, Lei Xiang, Xiaorong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
17β-estradiol
hepatocellular carcinoma
oxidative stress
apoptosis
foxo3a phosphorylation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.607379/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.607379/full

Similar Items