Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis

Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis

Cholesterol biosynthesis is a multi-step process involving several subcellular compartments, including peroxisomes. Cells adjust their sterol content by both transcriptional and post-transcriptional feedback regulation, for which sterol regulatory element-binding proteins (SREBPs) are essential; suc...

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Bibliographic Details
Main Authors: Khanichi N. Charles, Janis E. Shackelford, Phyllis L. Faust, Steven J. Fliesler, Herbert Stangl, Werner J. Kovacs
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cholesterol synthesis
CHO cells
ER-to-Golgi transport
peroxisomes
PEX2
SCAP
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.560266/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.560266/full

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