Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Colchicine is a well-known compound with strong antiproliferative activity that has had limited use in chemotherapy because of its toxicity. In order to create more potent anticancer agents, a series of novel colchicine derivatives have been obtained by simultaneous modification at C7 (amides and su...

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Bibliographic Details
Main Authors: Julia Krzywik, Witold Mozga, Maral Aminpour, Jan Janczak, Ewa Maj, Joanna Wietrzyk, Jack A. Tuszyński, Adam Huczyński
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
anticancer agents
colchicine amide
colchicine sulfonamide
tubulin inhibitors
docking studies
crystal structure
Online Access:https://www.mdpi.com/1420-3049/25/8/1789

Internet

https://www.mdpi.com/1420-3049/25/8/1789

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