Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells

Dexamethasone (DEX), a synthetic glucocorticoid, is commonly used as immunosuppressive and chemotherapeutic agent. This study was undertaken to investigate the effects of DEX on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in cancer cells. We found that upreg...

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Bibliographic Details
Main Authors: Mi-Yeon Jeon, Seon Min Woo, Seung Un Seo, Sang Hyun Kim, Ju-Ock Nam, Shin Kim, Jong-Wook Park, Peter Kubatka, Kyoung-jin Min, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
dexamethasone
TRAIL
DR5
c-FLIP(L), apoptosis
GSK-3β
Online Access:https://www.mdpi.com/2072-6694/12/10/2901

Internet

https://www.mdpi.com/2072-6694/12/10/2901

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