Diversity and evolution of four-domain voltage-gated cation channels of eukaryotes and their ancestral functional determinants

Abstract Four-domain voltage-gated cation channels (FVCCs) represent a large family of pseudo-tetrameric ion channels which includes voltage-gated calcium (Cav) and sodium (Nav) channels, as well as their homologues. These transmembrane proteins are involved in a wide range of physiological processe...

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Bibliographic Details
Main Authors: Ilya Pozdnyakov, Olga Matantseva, Sergei Skarlato
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21897-7