HCMB: A stable and efficient algorithm for processing the normalization of highly sparse Hi-C contact data

HCMB: A stable and efficient algorithm for processing the normalization of highly sparse Hi-C contact data

The high-throughput genome-wide chromosome conformation capture (Hi-C) method has recently become an important tool to study chromosomal interactions where one can extract meaningful biological information including P(s) curve, topologically associated domains, A/B compartments, and other biological...

Full description

Bibliographic Details
Main Authors: Honglong Wu, Xuebin Wang, Mengtian Chu, Dongfang Li, Lixin Cheng, Ke Zhou
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Hi-C
Normalization
Matrix balancing
Doubly stochastic matrix
Sparsity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001768

Internet

http://www.sciencedirect.com/science/article/pii/S2001037021001768

Similar Items