Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2′-Dibromo-2,4′,5′-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug

Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2′-Dibromo-2,4′,5′-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug

Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2&#8242;-dibromo-2,4&#8242;,5&#8242;-trihydroxydiphenylmethanone (<b>LM49-API</b>), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduce by-pr...

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Bibliographic Details
Main Authors: Xiu E Feng, Ke Meng Cui, Qing Shan Li, Zi Cheng Wu, Fei Lei
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone
process development
process-related impurity
acute pyelonephritis
polymorph
Online Access:https://www.mdpi.com/1420-3049/25/3/468

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https://www.mdpi.com/1420-3049/25/3/468

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