Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine

Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine

Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of protein–protein interaction networks. By dynamic association with their binding partners, SLiMs enable assembly of multiprotein complexes, pivotal for the regulation of various asp...

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Bibliographic Details
Main Authors: Mateusz Putyrski, Olesya Vakhrusheva, Florian Bonn, Suchithra Guntur, Andrew Vorobyov, Christian Brandts, Ivan Dikic, Andreas Ernst
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
phage display
selective autophagy receptor
LIR interaction
cytarabine
AML – acute myeloid leukemia
inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00208/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00208/full

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