Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells

Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells

A pivotal hallmark of some cancer cells is the evasion of apoptotic cell death. Importantly, the initiation of apoptosis often results in the activation of caspases, which, in turn, culminates in the generation of proteolytically-activated protein fragments with potentially new or altered roles. Rec...

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Bibliographic Details
Main Authors: Mohamed A. Eldeeb, Richard P. Fahlman, Mansoore Esmaili, Mohamed A. Ragheb
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
N-end-rule
cell death
protein degradation
apoptosis
N-terminal arginylation
proteases
caspases
proteolysis
ubiquitination
cancer biology
Online Access:https://www.mdpi.com/1422-0067/19/11/3414

Internet

https://www.mdpi.com/1422-0067/19/11/3414

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