Release of Prometastatic Platelet-Derived Microparticles Induced by Breast Cancer Cells: A Novel Positive Feedback Mechanism for Metastasis

Circulating platelets and platelet-derived microparticles are regulators of cancer metastasis. In this study, we show that breast cancer cells induce platelet aggregation and lead to the release of platelet-derived microparticles. Although able to cause comparable aggregation, the highly aggressive...

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Bibliographic Details
Main Authors: Marta Zarà, Gianni Francesco Guidetti, Daniela Boselli, Chiara Villa, Ilaria Canobbio, Claudio Seppi, Caterina Visconte, Jessica Canino, Mauro Torti
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2017-07-01
Series:TH Open
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1613674