Temporal bias in case-control design: preventing reliable predictions of the future

One of the primary tools that researchers use to predict risk is the case-control study. Here, the authors identify a flaw, temporal bias, that is specific to and uniquely associated with these studies that occurs when the study period is not representative of the data that clinicians have during th...

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Bibliographic Details
Main Authors: William Yuan, Brett K. Beaulieu-Jones, Kun-Hsing Yu, Scott L. Lipnick, Nathan Palmer, Joseph Loscalzo, Tianxi Cai, Isaac S. Kohane
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21390-2