Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction

Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction

Conventional protein kinase C βI (cPKCβI) is a conventional protein kinase C (PKC) isoform directly involved in the regulation of neurotransmitter release in the neuromuscular junction (NMJ). It is located exclusively at the nerve terminal and both synaptic activity and muscle contraction modulate i...

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Bibliographic Details
Main Authors: Erica Hurtado, Víctor Cilleros, Laia Just, Anna Simó, Laura Nadal, Marta Tomàs, Neus Garcia, Maria A. Lanuza, Josep Tomàs
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PDK1
cPKCβI
phosphorylation
neuromuscular junction
PKC
muscle contraction
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00270/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00270/full

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