Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight‐Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy

The pharmacokinetics (PKs) of sodium oxybate (SXB) was evaluated in a subset of participants from a study of SXB treatment in children (aged 7–11 years; n = 11) and adolescents (aged 12–17 years; n = 18) with narcolepsy with cataplexy. PK evaluation was conducted over 2 nights during the period when...

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Bibliographic Details
Main Authors: Cuiping Chen, Carol L. Rosen, Chad Ruoff, Leslie H. Boyce, Rupa Parvataneni, Katie Zomorodi, Scott Brantley, Mark Sale, Giuseppe Plazzi
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.12780