The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

Abstract Background Previous studies have identified critical roles of IL-27 in the pathological mechanisms of sepsis, and blockade of IL-27 may be a promising alternative therapy for sepsis. The purpose of this study was to evaluate the clinical relevance of IL-27 genetic polymorphisms in sepsis an...

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Bibliographic Details
Main Authors: Junbing He, Quanfu Zhang, Wenying Zhang, Feng Chen, Tian Zhao, Yao Lin, Jia Li, Yansong Liu, Yuchun Liu, Yiming Shao
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Critical Care
Subjects:
IL-27
Polymorphism
Sepsis
Inflammation
TNF-α
IL-1β
Online Access:http://link.springer.com/article/10.1186/s13054-018-2180-0

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http://link.springer.com/article/10.1186/s13054-018-2180-0

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