Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis

Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis

We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of encephalomyelitis and peaked when the patient fell int...

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Bibliographic Details
Main Authors: Henrik Zetterberg, Max Levin, Anna Rudin, Jan Borén, Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Fröjd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Malin Levin
Format: Article
Language:English
Published: BMJ Publishing Group 2021-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/7/e002732.full

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https://jitc.bmj.com/content/9/7/e002732.full

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