Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy has shown tremendous success in eradicating hematologic malignancies. However, this success has not yet been extrapolated to solid tumors due to the limited infiltration and persistence of CAR-T cells in the tumor microenvironment (TME). In t...

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Bibliographic Details
Main Authors: Feng Ji, Fan Zhang, Miaomiao Zhang, Kaili Long, Mingyue Xia, Fei Lu, Enjie Li, Jiannan Chen, Jun Li, Zhengliang Chen, Li Jing, Shaochang Jia, Rong Yang, Zhigang Hu, Zhigang Guo
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Hematology & Oncology
Subjects:
CAR
CD70
RCC
PARP
Renal carcinoma
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13045-021-01168-1

Internet

https://doi.org/10.1186/s13045-021-01168-1

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