VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways

VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways

We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the ability of VISTA agonistic antibodies to augment LPS...

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Bibliographic Details
Main Authors: Mohamed A. ElTanbouly, Evelien Schaafsma, Nicole C. Smits, Parth Shah, Chao Cheng, Christopher Burns, Bruce R. Blazar, Randolph J. Noelle, Rodwell Mabaera
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
VISTA
macrophage
tolerance
immunosuppression
agonist
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.580187/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.580187/full

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