In Situ Regulation of Macrophage Polarization to Enhance Osseointegration Under Diabetic Conditions Using Injectable Silk/Sitagliptin Gel Scaffolds

In Situ Regulation of Macrophage Polarization to Enhance Osseointegration Under Diabetic Conditions Using Injectable Silk/Sitagliptin Gel Scaffolds

Abstract As a chronic inflammatory disease, diabetes mellitus creates a proinflammatory microenvironment around implants, resulting in a high rate of implant loosening or failure in osteological therapies. In this study, macroporous silk gel scaffolds are injected at the bone–implant interface for i...

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Bibliographic Details
Main Authors: Geng Xiang, Keyin Liu, Tianji Wang, Xiaofan Hu, Jing Wang, Zhiheng Gao, Wei Lei, Yafei Feng, Tiger H. Tao
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Advanced Science
Subjects:
diabetes mellitus
injectable silk gel scaffold
macrophage polarization
osseointegration promotion
Online Access:https://doi.org/10.1002/advs.202002328

Internet

https://doi.org/10.1002/advs.202002328

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