Genetic and regulatory architecture of Alzheimer's disease in the APOE region

Genetic and regulatory architecture of Alzheimer's disease in the APOE region

Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease (AD). Methods We examined differences in linkage disequilibrium (LD) structures between (1) AD‐affected...

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Bibliographic Details
Main Authors: Alexander M. Kulminski, Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Irina Culminskaya
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
apolipoprotein E
linkage disequilibrium
Online Access:https://doi.org/10.1002/dad2.12008

Internet

https://doi.org/10.1002/dad2.12008

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