Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides

Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides

The process of pre-mRNA splicing is a common and fundamental step in the expression of most human genes. Alternative splicing, whereby different splice motifs and sites are recognised in a developmental and/or tissue-specific manner, contributes to genetic plasticity and diversity of gene expression...

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Bibliographic Details
Main Authors: May T. Aung-Htut, Craig S. McIntosh, Kristin A. Ham, Ianthe L. Pitout, Loren L. Flynn, Kane Greer, Sue Fletcher, Steve D. Wilton
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
antisense oligonucleotide
splice modulation
2′-<i>o</i>-methyl
transfection
Online Access:https://www.mdpi.com/1422-0067/20/20/5030

Internet

https://www.mdpi.com/1422-0067/20/20/5030

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