Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo; however, with the expanding repertoire of CRISPR/Cas endonucleases, it is n...

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Bibliographic Details
Main Authors: Fan Li, Kristof Wing, Jiang-Hui Wang, Chi D. Luu, James A. Bender, Jinying Chen, Qi Wang, Qinyi Lu, Minh Thuan Nguyen Tran, Kaylene M. Young, Raymond C. B. Wong, Alice Pébay, Anthony L. Cook, Sandy S. C. Hung, Guei-Sheung Liu, Alex W. Hewitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CRISPR (clustered regularly interspaced short palindromic repeats)
retina
retinal dystrophy
gene editing
AAV (adeno-associated virus)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.570917/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.570917/full

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