Early Events, Kinetic Intermediates and the Mechanism of Protein Folding in Cytochrome c

Early Events, Kinetic Intermediates and the Mechanism of Protein Folding in Cytochrome c

Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism, fluorescence energy and electron transfer, small-a...

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Bibliographic Details
Main Authors: David S. Kliger, Robert A. Goldbeck, Eefei Chen
Format: Article
Language:English
Published: MDPI AG 2009-04-01
Series:International Journal of Molecular Sciences
Subjects:
Collapsed intermediate
secondary structure formation
disordered tertiary structure
conformational diffusion
unfolded chains
molten globule
heme misligation
time-resolved spectroscopy
far-UV circular dichroism
magnetic circular dichroism
Trp59 fluorescence
amide hydrogen exchange
small-angle X-ray scattering
thermophiles
three-state pathway
Online Access:http://www.mdpi.com/1422-0067/10/4/1476/

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http://www.mdpi.com/1422-0067/10/4/1476/

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