Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

Abstract Background Oncogenesis rewires signaling networks to confer a fitness advantage to malignant cells. For instance, the B16F0 melanoma cell model creates a cytokine sink for Interleukin-12 (IL-12) to deprive neighboring cells of this important anti-tumor immune signal. While a cytokine sink p...

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Bibliographic Details
Main Authors: Christina N. Byrne-Hoffman, Wentao Deng, Owen McGrath, Peng Wang, Yon Rojanasakul, David J. Klinke
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell Communication and Signaling
Subjects:
Interleukins
Intracellular signaling
Cytokine
JAK-STAT signaling
PI3K-AKT signaling
Non-canonical
Online Access:http://link.springer.com/article/10.1186/s12964-020-00547-4

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http://link.springer.com/article/10.1186/s12964-020-00547-4

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