Paeonia japonica root extract protects hepatocytes against oxidative stress through inhibition of AMPK-mediated GSK3β

Paeonia japonica root extract protects hepatocytes against oxidative stress through inhibition of AMPK-mediated GSK3β

Paeonia japonica root has been widely used for its antioxidative, anti-inflammatory, and analgesic effects. This research investigated the effects of P. japonica root extract (PJE) on hepatotoxicity and the underlying molecular mechanisms. PJE blocked the arachidonic acid (AA) + iron-induced hepatot...

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Bibliographic Details
Main Authors: Hae Li Ko, Eun Hye Jung, Dae Hwa Jung, Jae Kwang Kim, Sae Kwang Ku, Young Woo Kim, Sang Chan Kim, Rongjie Zhao, Chul Won Lee, Il Je Cho
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Journal of Functional Foods
Subjects:
Paeonia japonica
Hepatotoxicity
Oxidative stress
AMPK
GSK3β
Histopathology
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615005435

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http://www.sciencedirect.com/science/article/pii/S1756464615005435

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