Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.

Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.

Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP(+)), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing...

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Bibliographic Details
Main Authors: Philip Wing-Lok Ho, Jessica Wing-Man Ho, Ho-Man Tse, Danny Hon-Fai So, David Chi-Wai Yiu, Hui-Fang Liu, Koon-Ho Chan, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3303587?pdf=render

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http://europepmc.org/articles/PMC3303587?pdf=render

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