Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechanism by which Aβ-induced neuronal excitability...

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Bibliographic Details
Main Authors: Ming Lei, Huixin Xu, Zhangyuan Li, Zemin Wang, Tiernan T. O'Malley, Dainan Zhang, Dominic M. Walsh, Pingyi Xu, Dennis J. Selkoe, Shaomin Li
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Aβ oligomers
Synaptic plasticity
Longterm potentiation
Epileptiform activity
Population spike
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300772

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http://www.sciencedirect.com/science/article/pii/S0969996115300772

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