Metoprolol alleviates arginine vasopressin-induced cardiomyocyte hypertrophy by upregulating the AKT1–SERCA2 cascade in H9C2 cells

Metoprolol alleviates arginine vasopressin-induced cardiomyocyte hypertrophy by upregulating the AKT1–SERCA2 cascade in H9C2 cells

Abstract Background Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality. Metoprolol (Met) is a beta blocker that is widely used in the clinic to treat pathological card...

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Bibliographic Details
Main Authors: Jieqiong Zhao, Yonghong Lei, Yanping Yang, Haibo Gao, Zhongchao Gai, Xue Li
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell & Bioscience
Subjects:
Arginine vasopressin
Metoprolol
AKT1
SERCA2
Cardiomyocyte hypertrophy
Online Access:http://link.springer.com/article/10.1186/s13578-020-00434-y

Internet

http://link.springer.com/article/10.1186/s13578-020-00434-y

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