Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin

In this work, optimal control techniques were used to optimize the feed of reactants during the enzymatic synthesis of ampicillin in a semi-batch reactor. Simulation results showed that a semi-batch integrated reactor (with product crystallization) might achieve 88% 6-APA (6-aminepenicillanic acid)...

Full description

Bibliographic Details
Main Authors: Marcelo Perencin de Arruda Ribeiro, Roberto de Campos Giordano
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2005-06-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400003