Biotin Protein Ligase Is a Target for New Antibacterials

Biotin Protein Ligase Is a Target for New Antibacterials

There is a desperate need for novel antibiotic classes to combat the rise of drug resistant pathogenic bacteria, such as Staphylococcus aureus. Inhibitors of the essential metabolic enzyme biotin protein ligase (BPL) represent a promising drug target for new antibacterials. Structural and biochemica...

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Bibliographic Details
Main Authors: Jiage Feng, Ashleigh S. Paparella, Grant W. Booker, Steven W. Polyak, Andrew D. Abell
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Antibiotics
Subjects:
antibiotic
biotin
biotin protein ligase
Staphylococcus aureus
inhibitor design
X-ray crystallography
in situ click chemistry
Online Access:http://www.mdpi.com/2079-6382/5/3/26

Internet

http://www.mdpi.com/2079-6382/5/3/26

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