C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort

C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort

Aim: To evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations. Methods: Our study comprised 757 male and female...

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Bibliographic Details
Main Authors: Tinashe Chikowore, Venesa Sahibdeen, Liesl M. Hendry, Shane A. Norris, Julia H. Goedecke, Lisa K. Micklesfield, Zané Lombard
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Journal of Clinical & Translational Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S2214623718301467

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http://www.sciencedirect.com/science/article/pii/S2214623718301467

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