Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

Normothermic perfusion provides a means to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new drug combinations to trigger defatting in three human culture models, primary hepatocytes with induced steatosis, primary hepatocytes isolat...

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Bibliographic Details
Main Authors: Lynda Aoudjehane, Jérémie Gautheron, Wilfried Le Goff, Claire Goumard, Julia Gilaizeau, Chan Sonavine Nget, Eric Savier, Muhammad Atif, Philippe Lesnik, Romain Morichon, Yves Chrétien, Yvon Calmus, Olivier Scatton, Chantal Housset, Filomena Conti
Format: Article
Language:English
Published: The Company of Biologists 2020-04-01
Series:Disease Models & Mechanisms
Subjects:
defatting
human hepatocytes
human precision-cut liver slices
liver transplantation
steatosis
triglycerides
Online Access:http://dmm.biologists.org/content/13/4/dmm042663

Internet

http://dmm.biologists.org/content/13/4/dmm042663

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