Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial.

The emergence of artemisinin resistance has raised concerns that the most potent antimalarial drug may be under threat. The currently recommended daily dose of artesunate (AS) is 4 mg/kg, and is administered for 3 days together with a partner antimalarial drug. This study investigated the impact of...

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Main Authors: Delia Bethell, Youry Se, Chanthap Lon, Stuart Tyner, David Saunders, Sabaithip Sriwichai, Sea Darapiseth, Paktiya Teja-Isavadharm, Phisit Khemawoot, Kurt Schaecher, Wiriya Ruttvisutinunt, Jessica Lin, Worachet Kuntawungin, Panita Gosi, Ans Timmermans, Bryan Smith, Duong Socheat, Mark M Fukuda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3094355?pdf=render