A Model for Osteonecrosis of the Jaw with Zoledronate Treatment following Repeated Major Trauma.

A Model for Osteonecrosis of the Jaw with Zoledronate Treatment following Repeated Major Trauma.

This study aims to develop a reproducible rat model for post-traumatic bisphosphonate-related osteonecrosis of the jaw (BRONJ). In our previous studies using dental extraction as an inducing factor, only 30%-60% of zoledronate-treated animals fulfilled the definition of clinical BRONJ. We modified t...

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Bibliographic Details
Main Authors: R Nicole Howie, James L Borke, Zoya Kurago, Asma Daoudi, James Cray, Ibrahim E Zakhary, Tara L Brown, J Nathan Raley, Loan T Tran, Regina Messer, Fardous Medani, Mohammed E Elsalanty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4505856?pdf=render

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http://europepmc.org/articles/PMC4505856?pdf=render

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