Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors. High levels of D-2-hydroxyglutarate inhibit the TET family of DNA demethylases and Jumonji family of histone demethylases and cause epigenetic ch...

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Bibliographic Details
Main Authors: Ryan Janke, Anthony T Iavarone, Jasper Rine
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Heterochromatin
D-2-Hydroxyglutarate
Isocitrate Dehydrogenase
Oncometabolite
Online Access:https://elifesciences.org/articles/22451

Internet

https://elifesciences.org/articles/22451

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